BDBM50012187 INDIRUBIN 2

SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccc(Br)cc12

InChI Key InChIKey=TYNCGTPANDPODX-WAVHTBQISA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50012187   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012187(INDIRUBIN 2)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012187(INDIRUBIN 2)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012187(INDIRUBIN 2)
Affinity DataIC50:  2.60E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed